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Professor Celia Morgan of University of Exeter, who has led the world's largest studies of KAT, discusses the therapeutic potential alongside rising concerns about recreational ketamine addiction in the UK.", "doi": null, "url": "https://psychedelicalpha.com/news/therapy-or-threat-uk-expert-warns-of-rising-ketamine-addiction-as-phase-iii-alcoholism-trial-launches", "source": "Psychedelic Alpha", "first_seen": "2026-06-07" }, { "id": "19d32e21ab77350b8845fe5b9a7b0957f0eafd42ba6d05185b8dd51cc9bb11eb", "title": "Protocol for intravenous ketamine treatment for patients with therapy-resistant depression", "compound": "ketamine", "type": "observational", "institution": "\u00d8stfold Hospital (The Ketamine Unit at DPS Nordre, \u00d8stfold Hospital)", "condition": "depression", "sample_size": null, "status": "other", "date": "2026-06-07", "outcome_summary": "Protocol describing intravenous ketamine treatment program for therapy-resistant depression at \u00d8stfold Hospital, including indication criteria (MADRS \u226520, failed \u22652 antidepressants), treatment procedures, dosage, psychotherapeutic integration, and safety monitoring framework. Version 1 dated November 2024.", "doi": null, "url": "https://psychedelicalpha.com/wp-content/uploads/2025/07/protokoll-ketaminbehandling-for-terapiresistent-depresjon-v1-nov.2024-1.pdf", "source": "Psychedelic Alpha", "first_seen": "2026-06-07" }, { "id": "5afab74003719ec8791fe3d495fa116e0bce5b57350b20f2377b2c8de1a0563a", "title": "Brain scans reveal how ketamine quickly lifts severe depression", "compound": "ketamine", "type": "observational", "institution": "Yokohama City University Graduate School of Medicine", "condition": "depression", "sample_size": 83, "status": "published", "date": "2026-06-07", "outcome_summary": "PET imaging with [11C]K-2 tracer showed that ketamine's antidepressant effects in treatment-resistant depression are mediated by dynamic, region-specific changes in AMPA receptor density in the living human brain, with some cortical areas showing increased receptor density and reward-processing regions like the habenula showing reductions.", "doi": null, "url": "https://www.sciencedaily.com/releases/2026/03/260307213234.htm", "source": "General News", "first_seen": "2026-06-07" }, { "id": "8ed7b4a28b26f510a318aac78b052414ca43440bf2c87770e2383e205a22e453", "title": "Drug combo is the first to prolong ketamine\u2019s antisuicide effects", "compound": "ketamine", "type": "other", "institution": "Stanford Medicine", "condition": "depression", "sample_size": null, "status": "other", "date": "2026-06-07", "outcome_summary": "A drug combination was found to be the first to prolong ketamine's antisuicide effects, though further research is needed to understand longer term effects and applicability to other types of depression such as bipolar disorder.", "doi": null, "url": "https://med.stanford.edu/news/all-news/2026/05/drug-ketamine-antisuicide-effects.html", "source": "General News", "first_seen": "2026-06-07" }, { "id": "2ddba848bc4ffae031bd00f0db8cdb1dc4aaeb098f67413e451d07f53cbe145b", "title": "Is Ketamine Still a Party Drug in 2026?", "compound": "ketamine", "type": "news", "institution": "Neuroscience Research Institute", "condition": "other", "sample_size": null, "status": "other", "date": "2026-06-07", "outcome_summary": "Article discusses ketamine's dual identity in 2026 as both a continuing recreational/party drug and an established medical treatment for mental health conditions. No specific study results or clinical trial outcomes reported.", "doi": null, "url": "https://www.neuroscienceresearchinstitute.com/is-ketamine-still-a-party-drug-in-2026", "source": "General News", "first_seen": "2026-06-07" }, { "id": "70a9b634327ac24ab6442b0d7fc81986d16a002077fd242763be043745e33722", "title": "Evidence and Experience: Samuel Wilkinson on the State of (Es)ketamine Therapy and What Comes Next", "compound": "ketamine", "type": "news", "institution": "Yale University", "condition": "depression", "sample_size": null, "status": "recruiting", "date": "2026-06-07", "outcome_summary": "Samuel Wilkinson of Yale is leading a large multi-site, open-label, randomized non-inferiority study comparing IV ketamine to intranasal esketamine (Spravato) for treatment-resistant depression. No comparative outcomes are yet reported; existing observational data suggesting IV ketamine may perform better are limited by non-randomized design and socioeconomic confounding.", "doi": null, "url": "https://psychedelicalpha.com/news/evidence-and-experience-samuel-wilkinson-on-the-state-of-esketamine-therapy-and-what-comes-next", "source": "Psychedelic Alpha", "first_seen": "2026-06-07" }, { "id": "977f5452539c7a41e14250f99c93ae0aa5a1c43f309ea9c985e0554d45118cb7", "title": "UCSF Ketamine Clinical Trials \u2014 San Francisco Bay Area", "compound": "ketamine", "type": "other", "institution": "UCSF", "condition": "other", "sample_size": null, "status": "other", "date": "2026-06-07", "outcome_summary": "This is a landing page listing multiple UCSF clinical trials involving ketamine across various conditions including Parkinson's disease, depression, status epilepticus, eating disorders, and methamphetamine use disorder.", "doi": null, "url": "https://clinicaltrials.ucsf.edu/ketamine", "source": "General News", "first_seen": "2026-06-07" }, { "id": "34faf1204e1f390f9a5f0ae33463dbc3657d28afda2f370321460bd9730394bb", "title": "Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial", "compound": "ketamine", "type": "phase_2", "institution": null, "condition": "depression", "sample_size": 168, "status": "published", "date": "2026-06-07", "outcome_summary": "The primary endpoint was met; the 180 mg extended-release ketamine tablet group showed a least square mean difference in MADRS score of -6.1 (95% CI 1.0 to 11.16, P = 0.019) compared to placebo at 13 weeks. Relapse rates showed a dose response from 70.6% for placebo to 42.9% for 180 mg. The treatment was well tolerated with no blood pressure changes, minimal sedation and dissociation.", "doi": "10.1038/s41591-024-03063-x", "url": "https://www.nature.com/articles/s41591-024-03063-x", "source": "General News", "first_seen": "2026-06-07" } ], "lsd": [ { "id": "1191fff6b77b695a4e807c1aa41eb5a8c1f69ba5efa756df6c07757c2d55ca05", "title": "LSD persistently disrupts affective pain processing.", "compound": "lsd", "type": "phase_2", "institution": null, "condition": "other", "sample_size": null, "status": "published", "date": "2026 May 1", "outcome_summary": null, "doi": "10.64898/2026.05.06.723205", "url": "https://pubmed.ncbi.nlm.nih.gov/42182358/", "source": "PubMed", "first_seen": "2026-06-07" }, { "id": "dcb0ab622c69c1edc2b440f1e5493156f382f53b33b530a322981e8b10e51243", "title": "Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)", "compound": "lsd", "type": "observational", "institution": "Northern Jiangsu People's Hospital", "condition": "other", "sample_size": 30, "status": "recruiting", "date": "2026-05-01", "outcome_summary": null, "doi": null, "url": "https://clinicaltrials.gov/study/NCT07585786", "source": "ClinicalTrials.gov", "first_seen": "2026-06-07" }, { "id": "e4293325660fccdb024c480583af2ca7b98d3a254b7bd0c96803cf49476c9a3a", "title": "LSD Treatment for Persons With Alcohol Use Disorder", "compound": "lsd", "type": "phase_2", "institution": "Felix Mueller", "condition": "other", "sample_size": 128, "status": "recruiting", "date": "2026-01-27", "outcome_summary": null, "doi": null, "url": "https://clinicaltrials.gov/study/NCT05474989", "source": "ClinicalTrials.gov", "first_seen": "2026-06-07" }, { "id": "71d90a90606717abf9bed3b0e00f781ecf4afa039982c85b22435cb706225f80", "title": "Long-term Efficacy and Safety of LSD Versus TIPS for Cirrhotic Portal Hypertension Bleeding and Hypersplenism", "compound": "lsd", "type": "observational", "institution": "Northern Jiangsu People's Hospital", "condition": "other", "sample_size": 140, "status": "recruiting", "date": "2026-06-01", "outcome_summary": null, "doi": null, "url": "https://clinicaltrials.gov/study/NCT07490405", "source": "ClinicalTrials.gov", "first_seen": "2026-06-07" } ], "dmt": [ { "id": "5972d42d2369ed24b0114f6394363ed5252d1d518d3a3cd4923997fd8e100c69", "title": "A Qualitative Study of Lived Treatment Experiences and Preferences of Long-Term DMT Users with Relapsing-Remitting Multiple Sclerosis.", "compound": "dmt", "type": "phase_2", "institution": null, "condition": "other", "sample_size": null, "status": "published", "date": "2026 Jun 5", "outcome_summary": null, "doi": "10.1007/s40120-026-00959-3", "url": "https://pubmed.ncbi.nlm.nih.gov/42247185/", "source": "PubMed", "first_seen": "2026-06-07" }, { "id": "c47d3db4d2b65db0097a1899ff354510320202c490fb3e1885f6740f747e5a8f", "title": "Speech markers of psychological change following a psychedelic 5-MeO-DMT retreat.", "compound": "dmt", "type": "phase_2", "institution": null, "condition": "other", "sample_size": null, "status": "published", "date": "2026 May 2", "outcome_summary": null, "doi": "10.1177/02698811261443690", "url": "https://pubmed.ncbi.nlm.nih.gov/42175700/", "source": "PubMed", "first_seen": "2026-06-07" }, { "id": "ecd7fa4359ce2de55f62df59431f6733b0e00075de02ff1669764c27e88f5af3", "title": "From monotherapy to sequential models: An updated scoping review on ibogaine\u2019s role in treatment for psychiatric disorders", "compound": "dmt", "type": "meta_analysis", "institution": null, "condition": "other", "sample_size": null, "status": "published", "date": "2026-01-01", "outcome_summary": null, "doi": "10.1177/02698811261443674", "url": "https://www.semanticscholar.org/paper/a8b5f01927c960ad525ac4d75a309ca0100325ee", "source": "Semantic Scholar", "first_seen": "2026-06-07" }, { "id": "2cb2ced6016f90f2fd9ed6ca40a046985efa0155a97786487338a2ed363efe24", "title": "Psychedelic Renaissance Progresses to Psychedelic Enlightenment", "compound": "dmt", "type": "other", "institution": null, "condition": "other", "sample_size": null, "status": "other", "date": "Fri, 27 Ma", "outcome_summary": null, "doi": null, "url": "https://chacruna.net/extended-state-dimethyltryptamine-dmt-psychedelic-renaissance-progresses-to-psychedelic-enlightenment/", "source": "Chacruna Institute", "first_seen": "2026-06-07" } ], "ibogaine": [ { "id": "75b5ba70f18aabdcb28fb2237d2d5346a6db7cc594af2bcfc94f20e141cb3df5", "title": "Ibogaine in the Vet Brain: Changes in Brain Metabolism and Connectivity After Ibogaine Administration in Veterans With Traumatic Brain Injury.", "compound": "ibogaine", "type": "phase_2", "institution": null, "condition": "other", "sample_size": null, "status": "published", "date": "2026 Jun", "outcome_summary": null, "doi": "10.1016/j.bpsc.2026.04.005", "url": "https://pubmed.ncbi.nlm.nih.gov/42250921/", "source": "PubMed", "first_seen": "2026-06-07" }, { "id": "8641ca1611ad0e57ad3736ab3422901a44fea59d80edc58cd251239b962294ac", "title": "Thirty Years of Ibogaine Research: A Literature Review on Clinical Perspectives.", "compound": "ibogaine", "type": "phase_2", "institution": null, "condition": "other", "sample_size": null, "status": "published", "date": "2026 Jun 1", "outcome_summary": null, "doi": "10.1097/JCP.0000000000002197", "url": "https://pubmed.ncbi.nlm.nih.gov/42228481/", "source": "PubMed", "first_seen": "2026-06-07" }, { "id": "e42140450f0294f28fd6b21f6e3e4de1bb51e536be5d249a574ca57a21dceb20", "title": "Exploring the Use of Ibogaine in Opioid Recovery: Insights from Lived Experience.", "compound": "ibogaine", "type": "phase_2", "institution": null, "condition": "other", "sample_size": null, "status": "published", "date": "2026 May 2", "outcome_summary": null, "doi": "10.1080/02791072.2026.2673843", "url": "https://pubmed.ncbi.nlm.nih.gov/42171381/", "source": "PubMed", "first_seen": "2026-06-07" }, { "id": "79dcfa6bda85b0172ce405a8038ad7e23af072a7a4fdd9095eba497811269011", "title": "An Uneasy Partnership?", "compound": "ibogaine", "type": "news", "institution": null, "condition": "addiction", "sample_size": null, "status": "other", "date": "Thu, 09 Ap", "outcome_summary": "Ibogaine is increasingly paired with 5-MeO-DMT in retreat settings, which complicates research data; ibogaine has shown improvements in executive function and reductions in PTSD, depression, and anxiety symptoms in study participants. Funding for ibogaine research has increased, including $50 million allocated in Texas.", "doi": null, "url": "https://chacruna.net/ibogaine-and-5-meo-dmt-an-uneasy-partnership/", "source": "Chacruna Institute", "first_seen": "2026-06-07" }, { "id": "39ad8516f66f706dfab11ab09db562a16b932ee5fbae45ccbd682c246ff8a77d", "title": "Trump Signs Executive Order To Fast-Track Psychedelic Research", "compound": "ibogaine", "type": "regulatory", "institution": "White House / U.S. Department of Health and Human Services / Department of Veterans Affairs", "condition": "PTSD", "sample_size": null, "status": "other", "date": "Tue, 21 Ap", "outcome_summary": "President Trump signed an executive order on April 18, 2026, directing federal agencies to reduce regulatory barriers and streamline FDA approval for psychedelic therapies, with a specific $50 million federal initiative to study ibogaine for veteran mental health and substance use disorders.", "doi": null, "url": "https://www.lucid.news/trump-signs-executive-order-designed-to-fast-track-psychedelic-research/", "source": "Lucid News", "first_seen": "2026-06-07" } ], "ayahuasca": [ { "id": "cafb92f2f8218313be976a39f2efc1b945873fe775d2d6e44afe6ebafc24eb2f", "title": "Not Many Patents Threaten Traditional Knowledge About Ayahuasca", "compound": "ayahuasca", "type": "other", "institution": null, "condition": "other", "sample_size": null, "status": "other", "date": "Wed, 20 Ma", "outcome_summary": "A detailed survey indicates that active patent requests implying undue appropriation of ayahuasca-based traditional knowledge are rare; the article argues that inaccurate or exaggerated information about patent threats spreads alarmism without factual basis and hinders negotiation between Indigenous communities and researchers.", "doi": null, "url": "https://chacruna.net/not-many-patents-threaten-traditional-knowledge-about-ayahuasca/", "source": "Chacruna Institute", "first_seen": "2026-06-07" }, { "id": "4551ce592f46b6cc2b7d9e643ba78ac7b18da0e0e964163e7e9509e60b33220e", "title": "Football Player Jordan Poyer Leads the Breath of Life Tour", "compound": "ayahuasca", "type": "news", "institution": "Luminate", "condition": "other", "sample_size": null, "status": "other", "date": "Wed, 13 Ma", "outcome_summary": "NFL player Jordan Poyer founded Luminate in 2024 and launched the \"Breath of Life\" tour, a modern ceremonial concert blending breathwork, sound healing, movement, and live music, with MAPS as a founding sponsor. The tour aims to scale access to psychedelic-informed healing modalities.", "doi": null, "url": "https://www.lucid.news/football-player-jordan-poyer-leads-the-breath-of-life-tour/", "source": "Lucid News", "first_seen": "2026-06-07" } ], "mescaline": [ { "id": "2ac64958a29e751eb98db25cec7cac838ef243b1710a4109546bb364adb42d4f", "title": "Mescaline Alters Cerebellar Function, Global Connectivity, and Frequency-Selective Acoustic Gating: A BOLD fMRI Study in Awake Rats.", "compound": "mescaline", "type": "phase_2", "institution": null, "condition": "other", "sample_size": null, "status": "published", "date": "2026 May 2", "outcome_summary": null, "doi": "10.1007/s12264-026-01632-3", "url": "https://pubmed.ncbi.nlm.nih.gov/42168715/", "source": "PubMed", "first_seen": "2026-06-07" } ], "other": [ { "id": "be3b21858d483c1edc937a7cb04cb7d8106ff2f5cccc8e92f2bcd8511d4abed2", "title": "OPTIMIZING EXTRACTION AND CONCENTRATION METHODS FOR LC-MS/MS ANALYSIS OF VETERINARY PHARMACEUTICALS IN 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"title": "High stakes: how legal cannabis pricing impacts the illicit market.", "compound": "other", "type": "phase_2", "institution": null, "condition": "other", "sample_size": null, "status": "published", "date": "2026 Jun 6", "outcome_summary": null, "doi": "10.1186/s42238-026-00455-3", "url": "https://pubmed.ncbi.nlm.nih.gov/42249514/", "source": "PubMed", "first_seen": "2026-06-07" }, { "id": "1ab02d23815dc4ec36c61ca97b8104d6956380f9a63a33bd03cdd1279b88c261", "title": "The effect of treatments for postpartum depression on breastfeeding practices: a systematic review and meta-analysis.", "compound": "other", "type": "meta_analysis", "institution": null, "condition": "depression", "sample_size": null, "status": "published", "date": "2026 Jun 1", "outcome_summary": null, "doi": "10.1016/j.midw.2026.104885", "url": "https://pubmed.ncbi.nlm.nih.gov/42248094/", "source": "PubMed", "first_seen": "2026-06-07" }, { "id": "03b56c6254effe8e586fc0dc7048568dfacbd8f299628513f61bd69c4f17def4", 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"Multidisciplinary Association for Psychedelic Studies (MAPS)", "condition": "other", "sample_size": null, "status": "other", "date": "2026-06-07", "outcome_summary": "MAPS issued a statement welcoming a federal Executive Order directing $50 million in funding to accelerate research on psychedelic compounds including ibogaine, psilocybin, LSD, and MDMA for serious mental illness, while emphasizing the need for rigorous science, ethical frameworks, and collaboration with Indigenous communities.", "doi": null, "url": "https://maps.org/2026/04/18/maps-welcomes-federal-action-to-advance-science-driven-psychedelic-research-and-policy", "source": "General News", "first_seen": "2026-06-07" }, { "id": "6c933f6b19f84246f598b13bd262fc2f69d5309ebb4283c27dd8fafe6d693167", "title": "Psychedelics & Healing Initiative Trends for 2026", "compound": "other", "type": "news", "institution": "Global Wellness Institute", "condition": "other", "sample_size": null, "status": "other", "date": "2026-06-07", "outcome_summary": "The article provides an industry overview of psychedelic medicine trends, noting that eight psychedelic candidates have received FDA 'breakthrough therapy' designations and seven have reached FDA Phase 3 trials. It highlights increasing bipartisan political support and FDA receptiveness to novel psychedelic compounds for integration into the healthcare system.", "doi": null, "url": "https://globalwellnessinstitute.org/global-wellness-institute-blog/2026/04/02/psychedelics-healing-initiative-trends-for-2026", "source": "General News", "first_seen": "2026-06-07" }, { "id": "28dca7e56efb37695c2a215a4ce215219dcd3e906505d560a4ea7975386591e5", "title": "Just a moment...", "compound": "other", "type": "other", "institution": null, "condition": "other", "sample_size": null, "status": "other", "date": "2026-06-07", "outcome_summary": null, "doi": null, "url": "https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2840552", "source": "General News", "first_seen": "2026-06-07" }, { "id": "87602c9461f80b04ecc876275197921fb2d60753b3672b173a4df23e22506992", "title": "Psychedelic Drug Development Tracker", "compound": "other", "type": "other", "institution": null, "condition": "other", "sample_size": null, "status": "other", "date": "2026-06-07", "outcome_summary": null, "doi": null, "url": "https://psychedelicalpha.com/resources/psychedelic-drug-development-tracker", "source": "General News", "first_seen": "2026-06-07" } ] } }